Thrombosis, phlebitis, and varicose veins

Thrombomodulin promoter mutations, venous thrombosis, and varicose veins.

We analyzed the distal promoter region of the thrombomodulin (TM) gene (nucleotides -300 to -2052) in subjects from the Paris Thrombosis Study (PATHROS), a French case-control study of venous thrombosis, to identify polymorphisms that might modify TM gene expression. Eight novel mutations were found in the 40 DNA samples initially screened. Two of these mutations (-1748G/C and -1208/-1209 del T...

Varicose Veins

Under normal circumstances, blood collected from superficial venous capillaries is directed upward and inward via one-way valves into superficial veins. These in turn drain via perforator veins, which pass through muscle fascia into deeper veins buried under the fascia. Leakage in a valve causes retrograde flow back into the vein. Unlike deep veins which are thick-walled and confined by fascia,...

Involvement of Varicose Veins in Superficial Venous Thrombosis

Varicose veins are usually a sign of a benign disease, however with progression of the disease and advanced age, they can lead to serious clinical problem. Beside chronic venous insufficiency, superficial venous thrombosis (SVT) represents one of the most frequent complications which can complicate with deep venous thrombosis (DVT) and pulmonary embolism. Classical risk factors for SVT are simi...

Varicose Veins

Phlebitis and Thrombosis